DNA Damage Response and Metabolic Disease

Cellular metabolic response to DNA damage

DNA damage elicits a cellular signaling response that initiates cell cycle arrest and DNA repair. The metabolic response to DNA damage is largely unknown. Here we report a novel metabolic response to genotoxic stress. DNA damage triggers a critical block in the uptake of glutamine, a mitochondrial substrate essential for cellular proliferation. Sirtuins regulate both cellular metabolism and str...

DNA damage response and neuroprotection.

The protection of genomic integrity is a major challenge for living cells that are continuously exposed to endogenous and environmental DNA-damaging insults. To cope with the consequences of DNA lesions which interfere with essential DNA-dependent processes including transcription and replication, cells are equipped with an efficient defense mechanism termed the DNA damage response. Its functio...

Radiation track and DNA damage

DNA Damage Response Pathways

ownload B4 is unusual among receptor tyrosine kinases because some isoforms can be efficiently cleaved at the a membrane to release a soluble intracellular domain. The cleavage product has high kinase activity mes to the nucleus. A screen for proteins that associate with the ErbB4 intracellular domain identified ate interactors including ITCH, WWP2, Nucleolin, and Krab-associated protein 1 (Kap...

DNA damage, DNA repair and disease

Damage to cellular DNA can result in the loss of genetic information, in cellcycle arrest or even in cell death. So DNA is constantly surveyed for the presence of lesions and appropriate responses are mounted: failure can lead to genomic instability, mutations and ultimately cancer. In the last few years, rapid progress has been made in understanding many aspects of DNA repair. For example, it ...